The α and Δ Isoforms of CREB1 Are Required to Maintain Normal Pulmonary Vascular Resistance
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چکیده
منابع مشابه
The α and Δ Isoforms of CREB1 Are Required to Maintain Normal Pulmonary Vascular Resistance
Chronic hypoxia causes pulmonary hypertension associated with structural alterations in pulmonary vessels and sustained vasoconstriction. The transcriptional mechanisms responsible for these distinctive changes are unclear. We have previously reported that CREB1 is activated in the lung in response to alveolar hypoxia but not in other organs. To directly investigate the role of α and Δ isoforms...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0080637